Seattle hosts the San Francisco 49ers this week. This is the first game against San Francisco this year, and they won’t play again until the last week in the regular season. If Seattle doesn’t want that to be a meaningful game, they need to win this one. Last week Seattle lost its first game of the year to Arizona in overtime. It was a game they let slip away.

This week they play a 49ers team that is 4-3 on the season and continues to have injuries pile up on their roster. Running back Jeff Wilson is out until week 12 after suffering a high ankle sprain last week against the Patriots. Raheem Mostert, the 49ers top running back, has been placed on injured reserve, and the earliest he will play in week 10. Former Seahawk Richard Sherman is also out with a calf injury and is not expected to return until week 10. Wide receiver Deebo Samuel is listed as doubtful for this week’s game. Both safeties for San Francisco didn’t play last week due to injury and are listed as questionable this week. Even though quarterback Jimmy Garoppolo came back from an ankle injury last week, he has never run well and only made one attempt for four yards last week.

With all of San Francisco’s injuries, especially to their running game, this should be a good time for Seattle to get back to their winning ways even as the defense continues to struggle. Look for Russell Wilson to have a better week and lead Seattle to a victory.